The current state of brucellosis in humans

Abstract

ABSTRACT

Brucellosis, an infectious disease caused by bacteria of the genus Brucella, has drawn the attention of healthcare providers worldwide because it causes occupational diseases and is regarded as an emerging disease and a potential agent for bioterrorism by the World Health Organization. Brazil does not have a structured public health network for brucellosis diagnosis in humans. This work aims to provide an update on its main aspects of this disease. A systematic literature review was conducted for this purpose. Etiological, clinical, epidemiological and diagnostic aspects were reviewed, among others, in order to update professionals and researchers in the field. A total of 31 articles were found, of which 28 were used. This review shows that many aspects of pathogenesis, prevention, diagnosis and therapy of the disease are not yet fully understood, but substantial progress has been made in understanding the molecular basis of Brucella genetics and the pathogenesis of infection. We conclude by stating the importance of standardizing the diagnostic procedures of the disease because surveillance measures are imposed based on data provided by these diagnoses.