Doenças fúngicas sistêmicas em pacientes internados em um hospital público de referência em Belém, estado do Pará, Amazônia brasileira

Yumi de Oliveira  Ohnishi; Antonio Saulo Leão Pantoja; Luciano Sami de Oliveira Abraão; Natália Guedes Alves; Maria Deise de Oliveira  Ohnishi; Rosana Maria Feio Libonati; Ana Maria Revorêdo da Silva  Ventura; Vera Regina da Cunha Menezes  Palácios

doi:10.5123/S2176-6223202200950

Authors

Yumi de Oliveira Ohnishi Universidade do Estado do Pará, Belém, Pará, Brasil https://orcid.org/0000-0001-7469-2458
Antonio Saulo Leão Pantoja Universidade do Estado do Pará, Belém, Pará, Brasil https://orcid.org/0000-0002-3888-0037
Luciano Sami de Oliveira Abraão Universidade do Estado do Pará, Belém, Pará, Brasil https://orcid.org/0000-0003-1733-1116
Natália Guedes Alves Universidade do Estado do Pará, Belém, Pará, Brasil https://orcid.org/0000-0002-1894-4371
Maria Deise de Oliveira Ohnishi Universidade do Estado do Pará, Belém, Pará, Brasil https://orcid.org/0000-0003-1554-5735
Rosana Maria Feio Libonati Universidade Federal do Pará, Núcleo de Medicina Tropical, Belém, Pará, Brasil https://orcid.org/0000-0002-1425-7806
Ana Maria Revorêdo da Silva Ventura Universidade do Estado do Pará, Belém, Pará, Brasil https://orcid.org/0000-0002-4737-1533
Vera Regina da Cunha Menezes Palácios Universidade do Estado do Pará, Belém, Pará, Brasil https://orcid.org/0000-0003-0300-7972

DOI:

https://doi.org/10.5123/S2176-6223202200950

Keywords:

Mycoses, Immunocompetence, Human Immunodeficiency Virus

Abstract

ABSTRACT

OBJECTIVE:

To determine the prevalence of systemic fungal diseases and the clinical and epidemiological aspects of patients affected and hospitalized at the João de Barros Barreto University Hospital in Belém, Pará State, Brazil.

MATERIALS AND METHODS:

It was a cross-sectional study carried out by searching the hospital's database, using the International Classification of Disease (ICD-10) from 2008 to 2017, with subsequent analysis of the demographic, epidemiological, and clinical aspects of patients.

RESULTS:

A total of 859 records of systemic fungal diseases were found, with a prevalence of 2.5% over the number of hospitalizations. The fungal pathologies diagnosed were candidiasis (41.2%), cryptococcosis (36.1%), histoplasmosis (10.0%), aspergillosis (5.5%), paracoccidioidomycosis (3.8%), pneumocystis (2.0%), unspecified mycoses (1.2%), and mucormycosis (0.2%). Most patients were male (61.7%), age group 20-59 years (81.8%), with a median of 34 years old, from the Metropolitan Area of Belém (61.5%), and had 1 to 3 years of schooling. Two-thirds of the patients had HIV/AIDS, and death was a determining factor for the shorter hospital stay in this group (p < 0.05). Of the total number of patients, 19.7% died, and the main cause was cryptococcosis. Comorbidities and complications did not influence the number of deaths.

CONCLUSION:

Fungal diseases remain an important cause of death, especially in immunosuppressed patients. Cryptococcosis still causes significant morbidity and mortality, being a global challenge.