The frequency of HLA-DRB1 polymorphisms in Brazilian Plasmodium vivax malaria patients and in blood donors from the Amazon Region

Luciane Moreno Storti-Melo; Daniela Reis da Costa; Wanessa Christina Souza-Neiras; Gustavo Capatti Cassiano; Cláudia Regina Bonini-Domingos; Andrea Regina Baptista Rossit; Luiz Carlos de Mattos; Ricardo Luiz Dantas Machado

doi:10.5123/S2176-62232010000400008

Authors

Luciane Moreno Storti-Melo Universidade Estadual Paulista "Júlio de Mesquita Filho", São José do Rio Preto, São Paulo, Brasil
Daniela Reis da Costa Universidade Estadual Paulista "Júlio de Mesquita Filho", São José do Rio Preto, São Paulo, Brasil
Wanessa Christina Souza-Neiras Universidade Estadual Paulista "Júlio de Mesquita Filho", São José do Rio Preto, São Paulo, Brasil
Gustavo Capatti Cassiano Universidade Estadual Paulista "Júlio de Mesquita Filho", São José do Rio Preto, São Paulo, Brasil
Cláudia Regina Bonini-Domingos Universidade Estadual Paulista "Júlio de Mesquita Filho", São José do Rio Preto, São Paulo, Brasil
Andrea Regina Baptista Rossit Instituto Biomédico, Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brasil
Luiz Carlos de Mattos Laboratório de Imunohematologia, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, São Paulo, Brasil
Ricardo Luiz Dantas Machado Centro de Investigação de Microrganismos, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, São Paulo, Brasil

DOI:

https://doi.org/10.5123/S2176-62232010000400008

Keywords:

Malaria, Plasmodium vivax, MHC Class II genes

Abstract

ABSTRACT

We evaluated the frequency of different HLA-DRB1 alleles in Plasmodium vivax-infected individuals and in healthy blood donors from malaria endemic areas of Brazil. Low-resolution human leukocyte antigen-DRB1 genotyping was performed for 73 malaria patients and 29 healthy blood donors. The most frequent alleles in individuals from northern Brazil were human leukocyte antigen-DRB1^*04, ^*08, ^*07 and ^*13. The frequency of human leukocyte antigen-DRB1^*07 was higher in malaria-infected individuals than in the control group, which reinforces the theory that this allele plays an important role in susceptibility to malaria. This study offers new information about a potential susceptibility factor for P. vivax malaria in a Brazilian population that is naturally exposed to malaria.