Perfil de anticorpos anti-PGL-1 em indivíduos sadios de áreas endêmicas para a hanseníase do Estado do Pará, Brasil*

Maria Heliana Chaves Monteiro da Cunha; Maria do Perpétuo Socorro Amador Silvestre; Marcos Fabiano de Almeida Queiroz; Marília Brasil Xavier

doi:10.5123/S2176-62232012000300005

Authors

Maria Heliana Chaves Monteiro da Cunha Núcleo de Medicina Tropical, Universidade Federal do Pará, Belém, Pará, Brasil
Maria do Perpétuo Socorro Amador Silvestre Laboratório de Hanseníase, Seção de Bacteriologia e Micologia, Instituto Evandro Chagas/SVS/MS, Ananindeua, Pará, Brasil
Marcos Fabiano de Almeida Queiroz Núcleo de Medicina Tropical, Universidade Federal do Pará, Belém, Pará, Brasil
Marília Brasil Xavier Núcleo de Medicina Tropical, Universidade Federal do Pará, Belém, Pará, Brasil. Universidade do Estado do Pará, Belém, Pará, Brasil

DOI:

https://doi.org/10.5123/S2176-62232012000300005

Keywords:

Leprosy, Blood Donors, Endemic Diseases, Seroepidemiologic Studies

Abstract

ABSTRACT

The aim of this study was to describe the profile of IgM, anti-PGL-1 antibodies, ELISA method in blood donors in highly endemic and hyperendemic areas of leprosy in Pará State, Brazil, using the cut-off point (CP) ≥ 0.20. Other objectives were to correlate the anti-PGL-1 levels to demographic factors and BCG vaccine and identify the CP to anti-PGL-1 test based on the average levels. The results showed no statistical significance between sex, age, presence of BCG scar and anti-PGL-1 levels. Three PCs were identified: general, by blood bank and municipalities. With CP ≥ 0.13 (general), the seropositivity in variables doubled in absolute numbers from 15 to 36, it was not a statistically significant result (p > 0.05). The average levels of anti-PGL-1 were very low for high standard areas, and they did not reflect the magnitude of leprosy endemicity in these areas. The lower CP was more appropriate to the serological behavior that was identified in the present study.